In vivo Raman Spectroscopic Study of Suspected Melanoma Skin Lesions and Healthy Skin

verfasst von

Di Wu, Anatoly Fedorov Kukk, Steffen Emmert, Bernhard Roth

Abstract

Cutaneous melanoma is one of the most lethal types of skin cancer. Non-invasively distinguishing malignant melanoma from benign tumours has always been a challenge. In this paper, an OCT and co-localized Raman spectroscopic system was built and Raman spectroscopy was used to measure skin samples of suspected melanoma lesions and their surrounding healthy areas non-invasively and in vivo. The Raman spectral signal intensities of the lesions increased at 1320 cm-1 and 1650 cm-1, while the content of carotenoids decreased, compared to that of the healthy skin samples. The results of the Shapley analysis values showed that the spectral peaks at 1320 cm-1 and 1650 cm-1 had a more significant effect on the differentiation of lesions from normal skin. This result can be used to guide the diagnosis of melanoma based on Raman spectroscopy.

Organisationseinheit(en)

Hannoversches Zentrum für Optische Technologien (HOT)
PhoenixD: Simulation, Fabrikation und Anwendung optischer Systeme

Externe Organisation(en)

Universität Rostock

Typ

Aufsatz in Konferenzband

Publikationsdatum

11.08.2023

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Elektronische, optische und magnetische Materialien, Physik der kondensierten Materie, Angewandte Informatik, Angewandte Mathematik, Elektrotechnik und Elektronik

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1117/12.2670621 (Zugang: Geschlossen)