In vivo Raman Spectroscopic Study of Suspected Melanoma Skin Lesions and Healthy Skin

authored by

Di Wu, Anatoly Fedorov Kukk, Steffen Emmert, Bernhard Roth

Abstract

Cutaneous melanoma is one of the most lethal types of skin cancer. Non-invasively distinguishing malignant melanoma from benign tumours has always been a challenge. In this paper, an OCT and co-localized Raman spectroscopic system was built and Raman spectroscopy was used to measure skin samples of suspected melanoma lesions and their surrounding healthy areas non-invasively and in vivo. The Raman spectral signal intensities of the lesions increased at 1320 cm-1 and 1650 cm-1, while the content of carotenoids decreased, compared to that of the healthy skin samples. The results of the Shapley analysis values showed that the spectral peaks at 1320 cm-1 and 1650 cm-1 had a more significant effect on the differentiation of lesions from normal skin. This result can be used to guide the diagnosis of melanoma based on Raman spectroscopy.

Organisation(s)

Hannover Centre for Optical Technologies (HOT)
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines

External Organisation(s)

University of Rostock

Type

Conference contribution

Publication date

11.08.2023

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications, Applied Mathematics, Electrical and Electronic Engineering

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1117/12.2670621 (Access: Closed)