Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications

verfasst von

Abuelmagd M. Abdelmonem, Antonina Lavrentieva, Nadja C. Bigall

Abstract

Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (d_h = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications.

Organisationseinheit(en)

Institut für Technische Chemie
PhoenixD: Simulation, Fabrikation und Anwendung optischer Systeme

Typ

Artikel

Journal

Chemical papers

Band

78

Seiten

533-546

Anzahl der Seiten

14

ISSN

0366-6352

Publikationsdatum

01.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Chemie (insg.), Biochemie, Chemische Verfahrenstechnik (insg.), Wirtschaftsingenieurwesen und Fertigungstechnik, Werkstoffchemie

Elektronische Version(en)

https://doi.org/10.1007/s11696-023-03108-4 (Zugang: Geschlossen)