Implant-based direction of magnetic nanoporous silica nanoparticles

influence of macrophage depletion and infection

authored by

Janin Reifenrath, Hilke Catherina Janßen, Dawid Peter Warwas, Manfred Kietzmann, Peter Behrens, Elmar Willbold, Mykola Fedchenko, Nina Angrisani

Abstract

Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.

Organisation(s)

Institute of Inorganic Chemistry
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines

External Organisation(s)

Hannover Medical School (MHH)
University of Veterinary Medicine of Hannover, Foundation
Cluster of Excellence Hearing4all
NIFE - Lower Saxony Centre for Biomedical Engineering, Implant Research and Development

Type

Article

Journal

Nanomedicine: Nanotechnology, Biology, and Medicine

Volume

30

ISSN

1549-9634

Publication date

11.2020

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Bioengineering, Medicine (miscellaneous), Molecular Medicine, Biomedical Engineering, Materials Science(all), Pharmaceutical Science

Electronic version(s)

https://doi.org/10.1016/j.nano.2020.102289 (Access: Closed)