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Implant-based direction of magnetic nanoporous silica nanoparticles

influence of macrophage depletion and infection

authored by
Janin Reifenrath, Hilke Catherina Janßen, Dawid Peter Warwas, Manfred Kietzmann, Peter Behrens, Elmar Willbold, Mykola Fedchenko, Nina Angrisani
Abstract

Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.

Organisation(s)
Institute of Inorganic Chemistry
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines
External Organisation(s)
Hannover Medical School (MHH)
University of Veterinary Medicine of Hannover, Foundation
Cluster of Excellence Hearing4all
NIFE - Lower Saxony Centre for Biomedical Engineering, Implant Research and Development
Type
Article
Journal
Nanomedicine: Nanotechnology, Biology, and Medicine
Volume
30
ISSN
1549-9634
Publication date
11.2020
Publication status
Published
Peer reviewed
Yes
ASJC Scopus subject areas
Bioengineering, Medicine (miscellaneous), Molecular Medicine, Biomedical Engineering, Materials Science(all), Pharmaceutical Science
Electronic version(s)
https://doi.org/10.1016/j.nano.2020.102289 (Access: Closed)