Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

authored by

Maria Leilani Torres-Mapa, Manmeet Singh, Olga Simon, Jose Louise Mapa, Manan Machida, Axel Günther, Bernhard Roth, Dag Heinemann, Mitsuhiro Terakawa, Alexander Heisterkamp

Abstract

Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

Organisation(s)

Institute of Quantum Optics
Hannover Centre for Optical Technologies (HOT)
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines

External Organisation(s)

Laser Zentrum Hannover e.V. (LZH)
Keio University
NIFE - Lower Saxony Centre for Biomedical Engineering, Implant Research and Development

Type

Article

Journal

Sensors (Switzerland)

Volume

19

ISSN

1424-8220

Publication date

01.10.2019

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Analytical Chemistry, Biochemistry, Atomic and Molecular Physics, and Optics, Instrumentation, Electrical and Electronic Engineering

Electronic version(s)

https://doi.org/10.3390/s19194333 (Access: Open)
https://doi.org/10.15488/9274 (Access: Open)