Confocal raman microscopy in VIS for analysing conformational changes in channel proteins

authored by
Ann Kathrin Kniggendorf, David Schmidt, Carsten Zeilinger, Bernhard Roth
Abstract

Ion channels are crucial proteins of all cells capable of generating electrical signals, responsible for converting chemical or mechanical messages into electrical signals by rapidly altering the ion concentration within the cell upon activation of the channel gate. Ion channel gating is a rapid, complex process occurring within a few milliseconds and often several gate mechanisms can be found within one protein. For example, the human Connexin 26 alone is known to have plug gating, fast gating, and several chemical gating processes, the first two of which involve conformational changes within the protein [1-3].

Organisation(s)
Hannover Centre for Optical Technologies (HOT)
Centre of Biomolecular Drug Research (BMWZ)
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines
Type
Conference contribution
Publication date
2019
Publication status
Published
Peer reviewed
Yes
ASJC Scopus subject areas
Spectroscopy, Electronic, Optical and Magnetic Materials, Instrumentation, Atomic and Molecular Physics, and Optics, Computer Networks and Communications
Electronic version(s)
https://doi.org/10.1109/CLEOE-EQEC.2019.8872650 (Access: Closed)