Effect of PEG functionalization on the saturation magnetization of magnetic nanoporous core-shell nanoparticles

authored by: T. Herrmann, A. K. Schierz, M. Prediger, J. Reifenrath, J. Meißner, M. C. Wurz, P. Behrens
Abstract: The treatment of implant-associated infections is still a considerable issue in modern orthopaedical surgery. A promising candi-date to improve this situation are superparamagnetic, drug-loaded nanoparticles in combination with a magnetizable implant and an external magnetic field. This set-up can enhance the accumulation of the magnetic nanoparticles at the targeted implant, thus reducing the number of nanoparticles needed for a successful treatment. Important prerequisites for the superparamagnet-ic nanoparticles to be used are a high magnetization and a sufficiently long circulation time within the body. A poly(ethyleneglycol) (PEG) functionalization is widely used to increase the circulation time. Since the PEG functionalization adds mass to the nanoparticles and influences also other properties, we functionalized magnetic nanoporous silica nanoparti-cles (MNPSNPs) with PEG moieties of different chain length and studied the effect of the chain length on the saturation magnet-ization of the particles.
Organisation(s): Institute of Inorganic Chemistry
Institute of Microtechnology
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines
External Organisation(s): Hannover Medical School (MHH)
University of Veterinary Medicine of Hannover, Foundation
Cluster of Excellence Hearing4all
DLR-Institute of Quantum Technologies
Type: Article
Journal: International Journal on Magnetic Particle Imaging
Volume: 8
No. of pages: 4
ISSN: 2365-9033
Publication date: 21.03.2022
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Electronic, Optical and Magnetic Materials, Signal Processing, Radiology Nuclear Medicine and imaging, Computer Science Applications, Electrical and Electronic Engineering
Electronic version(s): https://doi.org/10.18416/ijmpi.2022.2203009 (Access: Open)