All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D

authored by

Johanna-Gabriela Walter, Lourdes S.M. Alwis, Bernhard Roth, Kort Bremer

Abstract

An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0–100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications.

Organisation(s)

Institute of Technical Chemistry
PhoenixD: Photonics, Optics, and Engineering - Innovation Across Disciplines
Hannover Centre for Optical Technologies (HOT)

External Organisation(s)

Napier University

Type

Article

Journal

Sensors (Switzerland)

Volume

20

No. of pages

12

ISSN

1424-8220

Publication date

27.11.2020

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Analytical Chemistry, Biochemistry, Atomic and Molecular Physics, and Optics, Instrumentation, Electrical and Electronic Engineering

Electronic version(s)

https://doi.org/10.3390/s20236771 (Access: Open)