Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

verfasst von

Maria Leilani Torres-Mapa, Manmeet Singh, Olga Simon, Jose Louise Mapa, Manan Machida, Axel Günther, Bernhard Roth, Dag Heinemann, Mitsuhiro Terakawa, Alexander Heisterkamp

Abstract

Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

Organisationseinheit(en)

Institut für Quantenoptik
Hannoversches Zentrum für Optische Technologien (HOT)
PhoenixD: Simulation, Fabrikation und Anwendung optischer Systeme

Externe Organisation(en)

Laser Zentrum Hannover e.V. (LZH)
Keio University
NIFE- Niedersächsisches Zentrum für Biomedizintechnik, Implantatforschung und Entwicklung

Typ

Artikel

Journal

Sensors (Switzerland)

Band

19

ISSN

1424-8220

Publikationsdatum

01.10.2019

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Analytische Chemie, Biochemie, Atom- und Molekularphysik sowie Optik, Instrumentierung, Elektrotechnik und Elektronik

Elektronische Version(en)

https://doi.org/10.3390/s19194333 (Zugang: Offen)
https://doi.org/10.15488/9274 (Zugang: Offen)